探索训练有素的免疫力,以补充猪群对Streptococcus suis的疫苗接种
Lidia Sánchez-Morales1, Marta Pérez-Sancho1, Teresa García-Seco2
1VISAVET Health Surveillance Centre, Complutense University of Madrid, 28040, Madrid, Spain; Department of Animal Health, Faculty of Veterinary Medicine, Complutense University of Madrid, 28040, Madrid, Spain.
将一个非活化的菌根菌免疫调节剂与Streptococcus suis疫苗结合起来,改善了猪的保护. 这种方法对加强对抗细菌感染的猪病预防策略充满希望.
科学领域:
- 兽医免疫学 兽医免疫学
- 猪的传染病 猪的传染病
- 天生免疫记忆天生的免疫记忆
背景情况:
- 瑞士杆菌 (Streptococcus suis) 导致严重的猪病,如败血症和脑膜炎.
- 由于血清型多样性,遗传变异和母体抗体干扰,控制是具有挑战性的.
- 在S. suis菌株中抗生素耐药性带来了进一步的困难.
研究的目的:
- 评估一个菌根细菌免疫调节剂 (dpB) 与S. suis疫苗相结合是否可以增强猪的保护.
- 为了评估活体和非活化的dpB配方的疗效.
- 调查对免疫反应和临床结果的影响.
主要方法:
- 32只猪被分为四组:仅接种疫苗,接种疫苗+活体dpB,接种疫苗+非活化dpB和对照组.
- 动物接收了两次免疫接种,随后受到S. suis血清型2的挑战.
- 通过细胞因子水平,ex vivo血刺激和细胞测定来测量免疫反应.
主要成果:
- 接种疫苗和非活化的dpB的猪显示细菌负载减少和肺部病变.
- 这一组在挑战后表现出较轻微的临床症状和较少的细菌传播.
- 在禁用dpB组中观察到挑战前细胞因子水平升高.
结论:
- 无活化dpB与S. suis疫苗接种相结合,为改善猪的保护提供了一个潜在的补充策略.
- 这种方法可能会增强宿主对抗S. suis感染的防御机制.
- 进一步的研究是有必要的,以了解机制和整合到疾病预防计划.
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