碳纳米管对肺部疾病的影响归因于职业和环境暴露
Afzaal Nadeem Mohammad1, Yesenia Moreno2, Garrett Grischo2
1Phoenix Children's Research Institute, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States of America.
Nanomedicine : nanotechnology, biology, and medicine
|October 25, 2025
概括
碳纳米管 (CNTs) 的广泛使用引发了对呼吸系统健康的担忧. 在动物模型中,CNT暴露会导致炎症,纤维化和类似喘的疾病,突出显示潜在的风险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 纳米技术纳米技术
背景情况:
- 碳纳米管 (CNTs) 越来越多地用于制造业,导致环境释放和公众暴露.
- 人们担心CNT对人类呼吸系统健康的潜在不良影响.
- 以前的研究表明,CNT暴露可以引发炎症反应和氧化应激.
研究的目的:
- 审查碳纳米管暴露对呼吸系统的影响.
- 讨论 CNT 诱导的肺病理背后的机制.
- 探索CNT在模拟肺部疾病中的实用性.
主要方法:
- 审查关于CNT和呼吸系统健康的现有科学文献.
- 在动物模型中分析涉及CNT吸入的研究.
- 检查连接CNT暴露与肺部疾病的流行病学数据.
主要成果:
- 在动物中,CNT的吸入会导致颗粒状炎症和肺纤维化.
- CNT暴露与TH2喘炎症有关.
- CNTs 破坏细胞外矩阵稳态,促进纤维细胞的重塑.
- 流行病学数据表明,CNT暴露与纤维/粒状肺部疾病之间存在联系.
结论:
- 暴露于CNT对呼吸系统健康构成重大风险,诱导炎症和纤维化.
- 需要进一步的机制研究才能充分理解CNT的毒性.
- 在研究环境中,CNT显示出作为模拟肺部疾病的工具的潜力.
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