在免疫系统受抑制的儿童和青少年中,对疫苗接种的SARS-CoV-2-特定免疫反应:一项前性观察性研究
Rossa Brugha1, Amanda Kirkham2, Jessica Bate3
1Cardiothoracic Transplantation, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom; National Institute for Health Research (NIHR) GOSH Biomedical Research Centre, London, United Kingdom.
接受免疫抑制剂治疗风湿病和器官移植的儿童表现出良好的疫苗反应. 然而,接受癌症化疗的儿童对COVID-19疫苗的抗体和T细胞反应明显受损.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科瘤学 儿科瘤学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 接受免疫抑制疗法的儿童和青少年 (CYP) 可能会减少疫苗反应.
- 在接受治疗的儿科患者中评估疫苗免疫性对公共卫生至关重要.
研究的目的:
- 为了比较性和细胞免疫反应BNT162b2接种疫苗在CYP与风湿性炎症条件 (RICs),后固体器官移植 (PSOT) 或癌症化疗与健康对照.
- 研究特定的免疫抑制治疗对儿科患者疫苗疗效的影响.
主要方法:
- 预期招募125名接受RIC,PSOT或癌症治疗的CYP (5-17岁) 患者.
- 测量抗SARS-CoV-2尖端抗体和BNT162b2疫苗接种后的T细胞反应.
- 对野生型和SARS-CoV-2变种 (BA5,XBB1.5) 的抗体中和的评估.
主要成果:
- 具有RIC和PSOT的CYP显示了接近健康对照的抗体和T细胞反应.
- 与RIC和PSOT组相比,接受癌症化疗的CYP显示出显著较低的抗体反应 (P < .0001).
- 在癌症组 (P = .009和P = .003) 与RIC和PSOT组相比,观察到T细胞反应减少.
结论:
- 患有RIC和PSOT的儿科患者在接种疫苗后获得强大的免疫反应,类似于健康个体.
- 在CYP中进行的癌症化疗大大损害了对COVID-19疫苗的幽默和细胞免疫反应.
- 研究结果强调,需要针对儿童癌症患者量身定制的疫苗接种策略和监测.
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