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一个基于能源景观的理论框架,用于理解活体系统中功能在动态组件相互作用下的自我组织

Ryunosuke Suzuki¹, Taiji Adachi²

¹Laboratory of Biomechanics, Department of Biosystems Science, Institute for Life and Medical Sciences, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan; Department of Micro Engineering, Graduate School of Engineering, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

|October 25, 2025

概括

生物系统通过组件相互作用自我组织. 本研究引入了一个框架,模拟由能源景观驱动的响应性行为和动态相互作用如何组织复杂的系统功能.

科学领域:

系统生物学系统生物学
理论生物学理论生物学
生物物理学的生物物理.

背景情况:

生物系统包括相互作用的组件 (分子,细胞,组织),这些组件根据外部相互作用改变内部状态.
组件级的响应性行为,如由于机械力导致的组织生长和重塑,驱动系统级的自我组织.
组件相互作用的动态变化显著影响系统功能的自我组织.

研究的目的:

开发一个理论框架,以了解组件级响应性行为如何通过动态相互作用导致系统函数的自我组织.
使用能量和能量率景观来建模组件的响应性内部状态变化.
以基于这些景观的时间变化来表示交互动态.

主要方法:

利用一个通用的梯度流模型来表示基于指定的能量和能量率景观的组件级响应性行为.
通过考虑环境状态的时间变化来制定交互动态,由组件级响应性行为驱动.
在案例研究中使用了经历形态变化的机械相互作用组织的简化模型.

主要成果:

证明了由于个体组织的形态变化而产生的应用力的时间变化是系统功能自我组织的关键决定因素.
展示了框架将组件级响应行为与新兴系统级组织联系起来的能力.
通过涉及机械组织相互作用的案例研究验证了理论框架.

结论:

通过能量和能量率景观的时间变化来表达相互作用动态,提供了一个强大的理论方法.
了解组件级响应性行为及其对交互动态的影响,对于破译系统自我组织至关重要.
拟议的框架提供了对推动复杂生物系统自我组织的基本机制的见解.

关键词:

能源景观能源景观一般化梯度流的流量.互动互动互动互动生活系统生活系统响应性行为是响应性的行为.

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