一级HLA表达塑造瘤的免疫微环境,并影响前列腺癌的预后
Pornlada Likasitwatanakul1,2, Carissa Besonen3, Alexander K Tsai1,4
1Department of Medicine, University of Minnesota-Twin Cities, Minneapolis, MN, 55455, USA.
Prostate cancer and prostatic diseases
|October 26, 2025
概括
前列腺癌 (PC) 显示了低的人类白细胞抗原 (HLA) 类I表达. 高HLA表达与免疫活性相关,但与HLA-A/B的生存时间较短,HLA-C的生存时间较长有关.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 人类白细胞抗原 (HLA) I类蛋白对T细胞相互作用至关重要.
- 与其他癌症相比,前列腺癌 (PC) 呈现出明显的HLA I类表达模式.
- 了解PC中的HLA表达对于阐明其免疫微环境和临床行为至关重要.
研究的目的:
- 为了研究前列腺癌中HLA类I的表达水平.
- 探索HLA类I表达与临床结果,分子特征和PC中的瘤免疫微环境之间的关联.
- 确定前列腺癌患者HLAI类表达的预后意义.
主要方法:
- 来自Caris生命科学数据库的8040个PC样本的分析,分层分为HLA高和HLA低的组.
- 基因组和转录基因组变化的比较,包括雄激素受体 (AR) 信号和免疫检查点分子.
- 使用 quanTIseq 推断免疫细胞分数,并与总生存期 (OS) 数据相关联.
主要成果:
- 前列腺癌在66种癌症类型中HLA-A, -B和 -C表达率最低.
- 高HLA瘤显示AR信号基因的表达增加,免疫检查点,以及上皮-介质细胞过渡标记.
- 高HLA-A/B表达与高TMB-H/MSI-H/dMMR状态和较短的OS相关,而高HLA-C表达与较长的OS相关.
结论:
- 在PC中HLA I类表达升高与特定的分子特征和免疫活性有关.
- 在PC中,HLA表达是免疫活性的潜在补充生物标志物.
- 考虑到HLA表达与遗传突变和转录基因标记一起,可能会提高PC预后.
相关概念视频
02:17The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
01:27Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
02:39lncRNA - Long Non-coding RNAs
9.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.7K