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In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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相关实验视频

Updated: Jan 14, 2026

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空间转录学:用大语言模型对英语文学进行文献计量分析.

Huiyang Li1,2, Haixiao Wu3, Wenjuan Ma4

  • 1Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.

Briefings in bioinformatics
|October 26, 2025
PubMed
概括

空间转录学 (ST) 研究正在迅速扩大,特别是在癌症和免疫学领域. 图书统计分析揭示了关键趋势,并强调了跨学科合作对未来进步的重要性.

关键词:
文献计量分析的分析空间转录学 空间转录学翻译学 翻译学 翻译学瘤微环境是一个微环境.

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科学领域:

  • 生物技术是生物技术.
  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 空间转录组学 (ST) 集成了空间和转录组数据,用于高分辨率的基因表达映射.
  • 对于理解细胞功能和疾病机制,特别是癌症和免疫学方面,ST已经变得至关重要.

研究的目的:

  • 对2015-2024年间的ST出版物进行文献计量分析.
  • 确定出版趋势,期刊发行和ST的新兴研究领域.

主要方法:

  • 从科学网数据库中获取的1197篇出版物的图书法分析.
  • 分析出版趋势,期刊发行和关键字的同时出现情况.

主要成果:

  • 从2021年开始,ST出版物的显著激增,在2023年发表了500篇论文.
  • 关键的新兴研究领域包括"瘤微环境"",免疫透"和"生物标志物发现".
  • 在发表ST研究的前10家期刊中,有5家来自"自然出版集团".

结论:

  • ST是一个快速发展的领域,有着显著的增长,特别是在癌症和免疫学研究中.
  • 国际合作和多学科团队对于推动ST研究至关重要.
  • 了解ST趋势对于指导未来研究影响和应用至关重要.