健康体重儿童的记忆表现和海马体积 家庭肥胖风险高和低的儿童
Melanie A Dratva1, Zoe L Lanman1, Amanda Bischoff-Grethe1
1Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Pediatric obesity
|October 26, 2025
概括
患有肥胖家族史的儿童表现出较差的记忆力和较小的海马体积,即使体重健康. 这表明潜在的家族风险会在体重增加发生之前影响大脑发育.
科学领域:
- 神经科学是一个神经科学.
- 儿科健康 儿科健康
- 认知科学 认知科学
背景情况:
- 与健康体重 (HW) 儿童相比,超重或肥胖 (OW / OB) 的儿童表现出认知功能和海马体积的减少.
- 目前尚不清楚,具有未来OW/OB家族风险的HW儿童是否也会经历这些差异.
研究的目的:
- 为了研究高 (HR) 与低 (LR) 的OW/OB家族风险的健康体重儿童的记忆性能和海马子子子体积.
主要方法:
- 与95名健康体重儿童 (8-11岁) 进行比较,分类为HR (43岁,双亲OW/OB) 或LR (52岁,双亲HW).
- 使用结构性MRI和记忆测试 (VLLT-Food-C,单词对,点位置).
- 使用线性模型分析了记忆得分和海马体子场体积 (CA1,CA3,DG,subiculum) 的群体差异.
主要成果:
- HR儿童的BMI高于LR儿童,尽管他们都是HW.
- 在特定的记忆任务中,LR儿童的表现优于HR儿童,包括VLLT-Food-Ccued回忆和词组延迟回忆.
- HR儿童表现出较小的双边全海马,CA1,DG和右CA3体积;在调整后,只有右DG仍然显著.
结论:
- 在健康体重的儿童中,记忆力缺陷和海马体积减少可能表明了对OW/OB的潜在家族倾向.
- 这些发现表明,肥胖的家族风险可以影响早期的认知功能和大脑结构,甚至在显著的体重增加之前.
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