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患有自闭症谱系障碍的儿童的维生素D和大脑体积之间的关联

Pu Tian¹, Miaoshui Bai², Yaqian Liang³

¹Department of Radiology, The First Hospital of Jilin University, Changchun, Jilin, China.

Pediatric research

|October 27, 2025

概括

维生素D水平会影响自闭症谱系障碍 (ASD) 的儿童的大脑结构. 较低的维生素D与灰质体积的改变有关,影响症状的严重程度和发展,这表明营养干预可能有所帮助.

科学领域:

神经科学是一个神经科学.
发育儿科发育儿科
营养科学营养科学

背景情况:

维生素D缺乏与自闭症谱系障碍 (ASD) 中的神经发育问题有关.
幼儿时期 (24-72个月) 对于神经发育和ASD诊断至关重要.
这项研究调查了维生素D对ASD儿童大脑结构和发育的影响.

研究的目的:

探索维生素D状态和ASD儿童大脑结构之间的关系.
分析维生素D如何影响症状严重程度和发育结果.
确定与维生素D相关的ASD中潜在的神经发育机制.

主要方法:

234名患有自闭症的儿童根据症状严重程度 (轻度至中度或重度) 和维生素D状态 (正常,不足,缺乏) 分类.
基于voxel的形态测量 (VBM) 评估了灰色物质体积 (GMV).
统计分析检查了GMV,维生素D水平,症状严重程度和发育系数之间的关联.

主要成果:

在维生素D子组中观察到灰质体积的显著差异,特别是在额头和小脑区域.
与ASD症状严重程度和发育功能相关的结构变化.
调解分析表明,额叶体积部分解释了维生素D与临床/发育结果之间的联系.

结论:

维生素D水平与ASD儿童的区域特异性灰质体积有显著的相关性.
这些结构差异调解了维生素D与临床/发育结果之间的关系.
维生素D可能是影响ASD神经发育的可修改因素,为有针对性的营养干预提供信息.

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