抗血管内皮生长因子用于管理周周皮皮质冠状腺新血管膜
Angelica Hanna1, Aswen Sriranganathan2, Peter Kertes3,4
1Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Eye (London, England)
|October 27, 2025
概括
抗血管内皮生长因子 (anti-VEGF) 治疗是安全有效的,用于治疗周周皮状冠状新血管膜 (pCNVM). 治疗方法,包括pro re nata (PRN) 方法,改善视力敏度和减少视网膜厚度.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 血管生物学 血管生物学
背景情况:
- 周 papillary 冠状腺新血管膜 (pCNVM) 是一种严重影响视力的疾病.
- 抗血管内皮生长因子 (anti-VEGF) 药物是一种潜在的治疗方式.
研究的目的:
- 审查关于抗VEGF治疗pCNVM的有效性和安全性的现有证据.
- 评估pCNVM的不同抗VEGF治疗策略.
主要方法:
- 在Medline,Embase和CINAHL (2000-2024) 的系统文献搜索.
- 包括10项研究 (269只眼睛) 评估pCNVM的抗VEGF.
- 遵守PRISMA指南和潜在注册 (PROSPERO) 的要求.
主要成果:
- 在8项研究中,最常见的策略是pro re nata (PRN).
- 在34个月的随访期间,平均每眼注射7次抗VEGF注射.
- 八项研究显示改善最佳校正视敏度 (BCVA),平均logMAR变化为0.092.
- 观察到黄斑和胸膜厚度降低;没有报告显著的并发症.
结论:
- 包括PRN在内的抗VEGF疗法是pCNVM的安全有效治疗方法.
- 改善视力敏度是pCNVM抗VEGF治疗的一个关键结果.
- 进一步的研究可能会探索最佳的治疗方案.
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