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危急疾病中明显的昼间温度节律模式肌肉病理:两项前性试验的二次分析

D Mewes^1,2, S Weber-Carstens¹, K Rubarth³

¹Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Annals of intensive care

|October 27, 2025

概括

患有重症肌肉病变 (CIM) 的重症患者表现出被破坏的白天温度节律,可能导致肌肉代谢. 在CIM患者中降低了幅度抑制,这表明他们对重症监护室 (ICU) 昼夜干扰的适应能力受损.

科学领域:

身体生理学身体生理学
时间生物学时间生物学
密集护理医学密集护理医学

背景情况:

关键疾病肌肉病变 (CIM) 是一种严重的疾病,其特征是肌肉疲弱,缩和代谢受损,导致死亡率增加和长期残疾.
循环节律对于骨肌肉平衡至关重要,但在重症监护室 (ICU) 患者中经常受到干扰.
这项研究调查了CIM和没有CIM的重症患者之间昼间体温节律的差异.

研究的目的:

为了比较患有CIM和没有CIM的重症患者的昼间体温节奏.
探索温度节律参数与肌肉缩,肌肉衰弱和胰岛素敏感性标志物之间的关系.
调查潜在的适应性反应,以对日间活动中断在ICU.

主要方法:

两项前性试验的二次分析,涉及32名CIM和30名非CIM患者,与16名健康的床上休息参与者相比.
应用于确定日间体温节律参数 (尺度,幅度,形) 的共分析.
用于组比较的非参数测试;评估节律参数和临床结果之间的相关性.

主要成果:

与健康对照组相比,CIM和非CIM组都表现出温度节律的显著相位变化.
与没有CIM患者相比,CIM患者表现出较低的温度节律尺度和更高的幅度.
在ICU住院期间,温度节律幅度的减少在CIM患者中不那么明显,与肌肉横截面积负相关.

结论:

在CIM和非CIM患者中,中断的昼间温度节律表明了ICU相关的昼夜干扰.
在ICU停留期间抑制的温度节律幅度可能是一种适应性反应,在CIM患者中抑制的抑制表明适应性降低.
这些发现表明,CIM中昼夜适应能力受损与肌肉代谢之间存在潜在的联系,这需要进一步的机制研究.

关键词:

身体温度身体温度循环节律的破坏循环节律的破坏循环节律是指循环节律的节奏.危急的疾病危急的疾病危急疾病肌肉病变严重疾病肌肉病变一天中节律的节奏.肌肉疲弱肌肉疲弱肌肉疲弱骨肌肉缩骨肌肉缩温度节律温度节律

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