通过等离子介导的超皮超声波光弹性贴片,用于有效的药物输送
Enze Huang1, Yichen Li1, Chengjie Wang1
1Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, 611731, P. R. China.
Advanced healthcare materials
|October 27, 2025
概括
一个新的激光激活贴片使用超声波来增强皮肤药物输送. 这种灵活的装置显著增加了活性成分如尼胺和维生素C的透率,为皮肤病治疗提供了一种新的方法.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 皮肤病学 皮肤病学
背景情况:
- 通过皮肤传递的药物被角质层所限制.
- 目前的方法需要化学增强剂或繁的有线声装置.
研究的目的:
- 展示一种灵活的激光激活贴片,用于增强透皮药物输送.
- 为了研究贴片产生超声波和改善皮肤透的能力.
主要方法:
- 开发了一种带有金色膜光声传感器的紧贴片.
- 该贴片将光学脉冲转换为中频超声波,以创建洞穴.
- 多物理模型和ex vivo猪皮肤试验被用于评估.
主要成果:
- 该补丁产生了显著的声压,模型和实验证实了这一点.
- 3分钟的暴露增加了尼亚辛胺的流量8到10倍,透到450微米.
- 维生素C的透率达到650微米,温度升高最小 (<3°C).
结论:
- 激光激活的化贴片是通过皮肤输送的一个有前途的平台.
- 它的无电池,可扩展的设计支持按需的皮肤学和化品应用.
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