多发性硬化症上肢功能的纵向建模:临床和社会人口学因素的关联
Farren Bs Briggs1, Jiayue Yang2, Karlo Toljan3
1Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Multiple sclerosis (Houndmills, Basingstoke, England)
|October 27, 2025
概括
诸如年龄较大,男性性别,某些种族,吸烟,公共保险和下肢损伤增加等因素与多发性硬化症 (MS) 上肢功能恶化有关. 这些因素也会导致随着时间的推移,手的不对称性更大.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 流行病学 流行病学
背景情况:
- 上肢损伤是多发性硬化症 (MS) 的常见和致残的后果.
- 对于影响MS患者上肢功能因素的了解有限.
研究的目的:
- 确定与随着时间的推移与上肢表现的变化相关的因素,在大批患有MS的个体中.
主要方法:
- 一项回顾性队列研究分析了来自4140名多发性硬化症患者 (14,544次观察) 的数据.
- 多变量重复测量分析检查了九洞测试 (9HPT) 倍数 (主导和非主导手) 和不对称性.
- 共同变量包括临床,人口和社会决定因素,与疾病持续时间的相互作用.
主要成果:
- 从长度上看,年龄较大,男性性别,西班牙裔和黑人种族,吸烟史,公共保险,下肢损伤较大,渐进性多发性硬化和抑郁症状与手部功能恶化有关.
- 这些因素,以及渐进的多发性硬化和抑郁症状,也与增加的手部不对称性有关.
- 男人和越来越严重的下肢损伤的个体表现出主导手的功能障碍和不对称的较快积累.
结论:
- 该研究确定了与MS上肢功能下降相关的特定的人口,临床和社会因素.
- 研究结果突出了高风险群体,并为未来的研究提供了有关在MS患者中保持上肢功能策略的信息.
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