曲的碳支持的双原子纳米酶与阿斯科布酸氧化酶活性,用于级联瘤催化疗法
Chenyue Jiang1, Shaobo Wang2,3, Sirui Li4
1Department of Chemistry, Capital Normal University, Beijing 100048, China.
ACS nano
|October 27, 2025
概括
这项研究引入了一种新型纳米酶,在曲的碳表面上具有双单原子位点,通过产生反应性氧物种和耗尽谷氨来增强其用于瘤治疗的催化活性.
科学领域:
- 纳米材料科学 科学 纳米材料科学
- 催化剂是一种催化剂.
- 生物医学工程 生物医学工程
背景情况:
- 单原子纳米酶活动取决于金属中心电子结构.
- 表面曲率对纳米酶活性部位的影响尚未得到充分研究.
- 目前的策略专注于协调原子,而不是支持曲率.
研究的目的:
- 研究支表面曲率对单原子纳米酶活性的影响.
- 开发一种用于增强瘤治疗的新型纳米酶.
- 探索在位反应性氧物种生成的催化级联.
主要方法:
- 将Fe-Cr双单原子位点固定在一个曲的N-化碳支上 (C-Fe1Cr1NC).
- 评估纳米酶活性:亚酸盐氧化酶 (AO),过氧化酶 (POD) 和谷氨氧化酶 (GSHOx).
- 在瘤模型中通过催化级联和反应性氧物种生成评估治疗疗效.
主要成果:
- C-Fe1Cr1NC显著增强了AO,POD和GSHOx类活动.
- 纳米酶有效地氧化了 Askorbic 酸,在现场产生了 H2O2.
- 这种H2O2为POD活动提供了燃料,产生了活性氧物种,并耗尽了强大的瘤杀伤作用的谷氨.
结论:
- 表面曲率是设计单原子纳米酶的关键因素.
- 开发的C-Fe1Cr1NC纳米酶为有效的瘤治疗提供了一个有前途的战略.
- 这项工作为在曲面上构建先进的纳米酶治疗方法提供了洞察力.
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