综合生命周期评估指南 合成中的可持续性:抗病毒莱特莫维尔作为案例研究
Sander Folkerts1,2, Maximilian G Hoepfner3,2, Gonzalo Guillén-Gosálbez3,2
1Department of Chemistry and Applied Biosciences, Laboratory of Organic Chemistry, ETH Zürich, 8093 Zürich, Switzerland.
Journal of the American Chemical Society
|October 27, 2025
概括
这项研究引入了一种新的代方法,通过生命周期评估 (LCA) 和逆合成来评估化学合成的可持续性. 它提高了数据准确性,以优化绿色化学和减少环境影响.
科学领域:
- 绿色化学和化学工程
- 可持续的化学合成
- 生活周期评估 (LCA)
背景情况:
- 由于生产数据有限,评估复杂化学合成的可持续性尤其具有挑战性.
- 现有的生命周期评估 (LCA) 方法难以获得数据的完整性,准确性和可靠性,从而阻碍了全面的可持续性评估.
- 越来越需要可靠的指标来评估和改善化学制造过程的环境性能.
研究的目的:
- 开发和展示一个代的,闭环的方法,将生命周期评估 (LCA) 与多步合成开发相结合.
- 通过回归合成来推断记录的数据和信息来解决LCA中有限的生产数据的挑战.
- 用抗病毒药物Letermovir作为案例研究,比较和对比不同合成途径的可持续性.
主要方法:
- 采用了一种代的闭环策略,将生命周期评估 (LCA) 和多步合成开发相结合.
- 通过回归合成从基本化学物质中推断出的信息来增强可持续性数据,以克服数据的局限性.
- 生命周期评估 (LCA) 适用于已公布的路径和新合成的Letermovir,将结果与过程质量强度 (PMI) 进行比较.
主要成果:
- 该研究成功实施了有机化学多层次可持续性评估的综合战略.
- 在两种合成途径的不对称催化和金属介导合中发现了影响可持续性的瓶.
- 这种方法显示了更高的准确性,促进了路线比较,并实现了针对性的可持续性优化.
结论:
- 开发的代LCA方法提高了复杂化学合成的可持续性评估的准确性和可靠性.
- 识别特定的过程瓶,如催化步骤,突显了可持续催化方法的持续创新的需要.
- 这一战略为优化化学合成的环境足迹提供了强有力的工具,考虑到全球变暖潜力,生态系统质量,人类健康和资源利用.
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