用利科提高抗癌治疗效率:对临床和临床前证据的全面审查
Ravichandran Vishwa1, Bethsebie Lalduhsaki Sailo1, Bandari BharathwajChetty1
1Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India.
Journal of biochemical and molecular toxicology
|October 27, 2025
概括
红色素莱科 (LYP) 是一种西红色素,当与化疗或辐射等治疗相结合时,可以增强癌症治疗效果. 需要进一步的临床研究来确认其作为有效的癌症治疗辅助剂的作用.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 百合素 (LYP) 是一种具有已知的抗癌潜力的胡卜素.
- LYP可以增强现有的抗癌药物的疗效.
- 它作为联合癌症治疗中的辅助剂的作用正在调查中.
研究的目的:
- 系统地审查烯在联合癌症治疗中的疗效.
- 在组合治疗中识别由LYP调节的关键瘤性途径和细胞过程.
- 评估LYP作为各种癌症治疗中的辅助剂的现有证据.
主要方法:
- 使用PubMed和ClinicalTrials.gov数据库进行文献调查.
- 遵守系统审查和元分析 (PRISMA) 准则的首选报告项目.
- 根据定义的资格标准,包括了45项相关研究.
主要成果:
- 百合素 (LYP) 组合疗法调节了关键的致癌途径 (JAK2,MAPK,Akt/mTOR,IGF-1R,Akt/EZH2/AR,PPARγ/LXRα/ABCA1).
- LYP影响NF-κB,IFN-γ,Nrf2活动,以及细胞过程,如自,亡和抗氧化剂防御.
- 观察到的效应包括与辐射,光动力疗法,化疗 (cisplatin,5-FU,taxanes,sorafenib) 和各种癌症中的植物化学物质的组合.
结论:
- 莱科 (LYP) 通过调节多个致癌途径和细胞过程,显示出作为联合癌症治疗中的辅助剂的潜力.
- 涉及LYP与辐射,化疗和其他药物的组合显示出有希望的临床前和早期临床效果.
- 强有力的临床验证对于确定LYP作为主流癌症治疗中的有效辅助剂至关重要.
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