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A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
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利用扭曲结构和平面结构的协同作用,开发NIR-II光热解热剂
Huilin Xie1,2, Wenjing Liu3,4, Shibo Cheng1
1Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Longgang, Shenzhen, Guangdong 518172, China.
ACS nano
|October 27, 2025
概括
研究人员开发了一种新的NIR-II光疗剂,4TPE-TB,用于增强癌症诊断和治疗. 该剂可实现精确的光成像和有效的光热疗法,导致瘤切除和免疫激活.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
背景情况:
- 在第二近红外 (NIR-II) 区域开发用于同时进行癌症诊断和治疗的双模光疗剂是有希望的,但具有挑战性的.
- 现有的NIR-II有机染料往往由于光子吸收和能量消耗不佳,限制了其光成像 (FLI) 和光热疗法 (PTT) 的效率.
- 克服这些局限性需要创新的分子设计来增强光吸收并最大限度地减少非辐射衰变途径.
研究的目的:
- 使用"平面核心 + 扭曲外围"策略设计和合成一种新的NIR-II光疗剂.
- 评估开发的药物的光物理性质,光成像和光热治疗疗效.
- 调查该药物在引发直接瘤切除和免疫系统激活癌症治疗中的潜力.
主要方法:
- 采用"平面核心 + 扭曲外围"的分子设计,制造出NIR-II光异常剂4TPE-TB.
- 描述了光物理性质,包括分子吸收性和光发射.
- 将4TPE-TB制成纳米颗粒用于体内研究,评估NIR-II FLI和PTT在癌症模型中的疗效.
主要成果:
- 4TPE-TB剂显示出高摩尔吸收率 (4.0 × 10^4 M^-1 cm^-1) 和在980nm激发波长的高效性能.
- 4TPE-TB的纳米粒子配方使高精度的NIR-II FLI和有效的PTT成为可能,从而在癌症模型中导致显著的瘤切除.
- 这些纳米粒子在直接破坏瘤和刺激免疫系统方面表现出双重作用,增强治疗结果.
结论:
- "平面核心 + 扭曲外围"分子设计是开发高效的NIR-II光疗剂的成功策略.
- 4TPE-TB纳米颗粒通过结合FLI和PTT提供了一个有前途的平台,用于精确的癌症诊断和治疗.
- 观察到的免疫激活突显了这种方法对综合癌症治疗策略的潜力.
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