在服用固体食物后,人类肠道液体的表征
Brecht Goovaerts1, Mare Oja1, Sepanta Ehtemam1
1Drug Delivery and Disposition, KU Leuven, Leuven 3000, Belgium.
Molecular pharmaceutics
|October 27, 2025
概括
固体食,与液体食不同,会改变人类肠道液体的组成和药物溶解. 这影响了药物开发的体外模型,突出了对食类型特定生物相关介质的需求.
科学领域:
- 胃肠道学和药物输送
- 肠液的物理化学特性 肠液的物理化学特性
背景情况:
- 关于人肠液 (HIF) 组成和药物溶解的现有数据主要使用液体食,告知模拟肠液发育.
- 食物的物理形式 (固体与液体) 显著影响胃肠道处理,药物处置和生物可用性.
研究的目的:
- 为了比较HIF的组成和溶解能力,固体食后 (SM-HIF) 与液体食衍生的HIF (LM-HIF).
- 评估餐的物理形式对药物产品开发的生物相关媒介开发的影响.
主要方法:
- 在固体和液体食后收集的时间依赖的食状态HIF样本.
- 在180分钟 (固体) 和90分钟 (液体) 的时间内分析了十二指肠液体成分 (脂质,胆盐,蛋白质,脂质).
- 评估了聚合SM-HIF和LM-HIF对七种脂性化合物的溶解能力.
主要成果:
- 摄入固体食物导致外源和内源成分的逐渐增加,脂质和蛋白质水平升高持续180分钟.
- 与LM-HIF相比,SM-HIF显示出减少的外源成分,但类似的内源成分.
- 在SM-HIF中,由于脂质含量较低,整体溶解能力下降,而细胞分数能力保持相似.
- SM-HIF的组成和溶解能力表现出高度的个体间变异性.
结论:
- 餐的物理形式显著影响食后人类肠液的组成和溶解能力.
- 当前的生物相关媒介可能无法充分代表SM-HIF,因此需要精细化,以便在药物开发中准确预测食品的影响.
- 特定于饮食类型的生物相关介质对于改善体外模型以更好地预测体内药物行为至关重要.
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