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Updated: Jun 25, 2026

In vivo 19F MRI for Cell Tracking
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In vivo 19F MRI for Cell Tracking

Published on: November 25, 2013

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新型化化合物的细胞内结合到碳化无水酶同型,通过细胞内F NMR进行探索

Azzurra Costantino1, Letizia Barbieri1,2, Simone Giovannuzzi3

  • 1CERM - Magnetic Resonance Center, University of Florence, via Luigi Sacconi 6, Sesto Fiorentino 50019, Italy.

Journal of medicinal chemistry
|October 27, 2025
PubMed
概括

这项研究引入了细胞内19F核磁共振,以追踪细胞内的药物相互作用. 化化合物显示出作为选择性抑制剂和药物开发的探针的前景.

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Monitoring Protein-Ligand Interactions in Human Cells by Real-Time Quantitative In-Cell NMR using a High Cell Density Bioreactor10:25

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相关概念视频

¹³C NMR: ¹H–¹³C Decoupling01:04

¹³C NMR: ¹H–¹³C Decoupling

The probability of having two carbon-13 atoms next to each other is negligible because of the low natural abundance of carbon-13. Consequently, peak splitting due to carbon-carbon spin-spin coupling is not observed in spectra. However, protons up to three sigma bonds away split the carbon signal according to the n+1 rule, resulting in complicated spectra.
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...