枣果类醇在西斯诱导的肝毒性治疗前和后的影响
Omowumi O Adewale1,2, Roseline F Oyelola1, Adeola B Adenmosun1
1Department of Biochemistry, Osun State University, P.M.B. 4494, Osogbo, Osun State, Nigeria.
Toxicology reports
|October 27, 2025
概括
日期水果 (DFP) 显示在老鼠中对甲诱导的肝损伤有保护作用. DFP表现出抗氧化和抗炎性质,减轻化疗相关的肝毒性.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 自然产品化学 自然产品化学
- 肝脏保护剂 肝脏保护剂
背景情况:
- 西斯是一种广泛使用的化疗药物,由于氧化应激和炎症,具有显著的肝毒性.
- 植物衍生的具有已知的抗氧化和抗炎性质.
- 来自日果 (Phoenix dactylifera) 的类化合物对西斯毒性的肝保护潜力在很大程度上尚未被探索.
研究的目的:
- 调查日果 (DFP) 对雄性Wistar大鼠的西斯普拉丁诱导的肝毒性的保护作用.
- 阐明DFP的植物化学成分和抗氧化能力.
- 评估DFP在缓解化疗引起的肝损伤方面的潜在作用.
主要方法:
- 雄性Wistar大鼠接受了DPP和/或西斯的治疗.
- 组织学,生化,炎症和氧化还原生物标志物分析在西斯普拉丁后进行.
- 描述了DFP的植物化学含量,结构特征和体外抗氧化活性.
主要成果:
- 西斯普拉丁显著增加了肝损伤标志物,脂质过氧化和氧化,同时降低了抗氧化酶活性.
- 通过组织学发现,DFP的使用显著地逆转了这些西斯普拉丁诱导的变化.
- DFP在体外表现出显著的抗氧化特性和有益的植物化学成分.
结论:
- 日期水果 (DFP) 显示出显著的肝脏保护作用,防止西斯诱导的肝损伤.
- DFP的抗氧化和抗炎作用有助于其保护能力.
- 作为癌症治疗中的补充剂,DPF显示出有前途,以减少化疗相关的肝毒性.
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