孤立的REM睡眠行为障碍与24小时休息活动措施的改变有关
Joseph R Winer1, Renske Lok2, Adrian Ekelmans2
1Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
概括
与健康人相比,患有孤立REM睡眠行为障碍 (iRBD) 的患者表现出24小时活动模式的中断,白天运动较少,夜间活动更多. 这些发现表明利维体病的早期迹象.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 运动障碍 运动障碍
背景情况:
- 孤立的REM睡眠行为障碍 (iRBD) 是莱维体疾病的前兆症状,包括帕金森病和莱维体痴呆症.
- 超过80%的iRBD患者进展到这些神经退行性疾病.
- 休息活动模式的破坏是帕金森病的已知预测因素,但在iRBD中没有很好的特征.
研究的目的:
- 调查基于加速度计的24小时活动测量是否显示iRBD患者的碎片化和变异性比健康对照患者更大.
- 在iRBD中使用先进的分析技术来描述休息活动模式.
主要方法:
- 38名iRBD患者和119名匹配的健康对照接受了24小时的活动监测,使用手腕穿戴的加速度计大约25天.
- 处理了原始的加速度计数据,以计算非参数和共因子活动指标.
- 功能主要成分分析 (fPCA) 用于检测24小时活动模式的差异.
主要成果:
- iRBD患者的整体活动水平显著降低,包括在最活跃的10小时内活动减少.
- 患有iRBD的个体在夜间时间显著增加了运动 (L5).
- fPCA发现,白天活动减少和夜间活动增加是iRBD患者观察到的关键差异.
结论:
- 休息活动节律的多个指标证实,24小时的活动指标在iRBD中发生了变化.
- 这些休息活动中断可能反映了睡眠-清醒调节电路的退化.
- 在iRBD中活动模式的改变代表了勒维体病的早期症状.
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