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在服用抗逆转录病毒药物的HIV感染个体中ABCB1多态性

HariOm Singh¹, Dharmesh Samani¹, Supriya D Mahajan²

¹Department of Molecular Biology, ICMR-National AIDS Research Institute, Pune, 411026, India.

AIDS research and treatment

|October 27, 2025

概括

在ABCB1基因中的遗传变异可能会影响HIV患者的抗逆转录病毒 (ARV) 相关的肝毒性. 某些ABCB1单元类型,如TC,与风险增加有关,而CC和TT单元类型显示出对肝损伤的保护作用.

科学领域:

药物基因组学药物基因组学
肝病学肝病学是一种肝病学.
传染性疾病传染性疾病

背景情况:

作为ABC载体的P-glycoprotein (P-gp) 影响药物的排泄和暴露.
该ABCB1基因与消除非核酸逆转录酶抑制剂 (NNRTIs) 有关.
在ABCB1的遗传变异可以影响药物暴露和毒性.

研究的目的:

研究ABCB1基因多态 (1236C/T和3435C/T) 与抗逆转录病毒 (ARV) 相关的肝毒性之间的关联.
探索ABCB1变异对艾滋病毒感染个体肝损伤严重性的影响.

主要方法:

一项涉及165名艾滋病毒感染者和155名健康对照者的横截面研究.
使用PCR-RFLP方法对ABCB1 1236C/T和3435C/T多态的基因定型.
分析基因型和哈普洛型与肝毒性的关联,考虑诸如酒精使用和特定ARV疗法 (例如尼维拉平) 等因素.

主要成果:

在TC类型表现出严重肝毒性风险增加的趋势 (OR=1.96,p=0.06).
CC和TT单元类型与严重肝毒性风险降低有关 (ORs范围从0.09到0.34,p<0.05).
1236TT基因型与内维拉平使用相结合,表明肝毒性严重程度的潜在风险 (OR=2.11,p=0.55).

结论:

ABCB1单双类型可能在调节ARV诱导的肝毒性严重程度方面发挥作用.
虽然个体多态性没有显著的关联,但TC单元型和1236TT基因型与尼维拉平使用表明了潜在的风险.
CC和TT单元型表现出保护作用,需要在更大的队列中进行进一步的研究.

关键词:

在ABC载体P-糖蛋白中,P-糖蛋白是ABC载体.与ARV相关的肝毒性艾滋病病毒艾滋病病毒艾滋病病毒遗传多形态的遗传多形态.哈普洛型是指一个类型.

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