2012年至2022年,73个国家和地区的抗发作药物消费:纵向趋势研究
Adrienne Y L Chan1,2, Andrew S C Yuen3,4, Yingfen Hsia5
1Aston School of Pharmacy, Aston University, Birmingham, UK.
EClinicalMedicine
|October 27, 2025
概括
全球抗发作药物 (ASM) 的使用在2012-2022年期间增加,而像 levetiracetam 这样的新药也在增加. 然而,酸仍然很常见,特别是在低收入国家,强调需要将处方与安全指南保持一致,以获得更好的治疗结果.
科学领域:
- 药物监督 药物监督 药物监督
- 全球健康 全球健康
- 神经学 神经学
背景情况:
- 抗发作药物 (ASM) 的使用在全球范围内有所不同,人们担心瓦尔酸盐的致病风险.
- 世界卫生组织 (WHO) 的指导方针建议孕育年龄的妇女选择更安全的替代品.
- 国际ASM消费趋势仍未得到充分研究.
研究的目的:
- 评估2012年至2022年ASM消费的跨国趋势.
- 在不断变化的政策和监管行动的背景下分析这些趋势.
- 为了确定ASM使用的区域和收入水平差异.
主要方法:
- 用药品销售数据 (IQVIA-MIDAS) 对73个国家 (2012-2022) 进行纵向趋势分析.
- 消费量表达为每1万居民每天定义的每日剂量 (DDD/TID).
- 线性混合模型用于估计跨地区和收入水平的趋势.
主要成果:
- 全球ASM消费量每年增长2.58%,东南亚的增长显著.
- 新的ASM如 levetiracetam (+21.72%) 和lamotrigine (+7.48%) 的消费量增长,而旧的消费量则下降.
- 酸仍然是全球使用最多的ASM,在中低收入和中高收入国家增长更快.
结论:
- 尽管越来越多地使用新的ASM,但酸的消费仍然存在,特别是在低收入环境中.
- 根据收入水平,各国在ASM获取和使用方面存在显著差异.
- 迫切需要将处方实践与安全指南协调一致,以改善管理中的患者结果.
相关概念视频
01:20Antiepileptic Drugs: Potassium Channel Activators
631
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
631
01:24Epilepsy and Seizures: Overview
1.1K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.1K
01:08Antiepileptic Drugs: Sodium Channel Blockers
1.6K
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
1.6K
01:20Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
814
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
814
01:18Antiepileptic Drugs: GABAergic Pathway Potentiators
1.2K
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.2K
01:24Mania and Antimanic Drugs: Overview
545
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
545