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营养影响肥胖反弹和心脏代谢结果在低出生体重儿童的潜在出生队列中的营养影响:研究协议

Neethu Thulaseedharan¹, Liss Maria Scaria¹, Srikant Ambatipudi¹

¹Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, 695011, India.

Wellcome open research

|October 27, 2025

概括

早期营养对低出生体重婴儿的长期健康有影响. 这项研究检查了养模式,脂肪反弹和DNA甲基化,以了解两年内心代谢健康状况.

科学领域:

儿科儿科儿科
营养科学营养科学
遗传学是一个遗传学.

背景情况:

早期的营养对长期的健康结果至关重要.
早期的营养不良可能会增加低出生体重儿童的脂肪和心脏代谢风险.
研究早期的养模式,脂肪反弹时间和DNA甲基化是了解这一群体心脏代谢健康的关键.

研究的目的:

研究早期养模式对低出生体重儿童两岁心脏代谢健康的影响.
为了检查脂肪反弹时间和心脏代谢结果之间的关联.
评估DNA甲基化在与脂肪生成和心脏代谢健康相关的关键基因中的作用.

主要方法:

对1400名低出生体重儿童 (出生体重<2500克) 的长度随访研究.
数据收集包括临床记录,社会人口统计信息,饮食实践,人体测量,血压,生物化学标记 (脂质谱,胰岛素耐药性),DNA甲基化分析,心声学,状动脉内膜介质厚度和神经发育评估.
在两岁时进行的后续评估.

主要成果:

(结果尚未提供,因为研究正在进行/招聘)

结论:

了解早期营养的影响对于促进低出生体重儿童心脏代谢健康至关重要.
量身定制的食干预措施对于保护这个脆弱群体的心血管健康至关重要.

关键词:

通过DNA甲基化.低出生体重低出生体重神经发育神经发育脂肪增加增加脂肪增加心脏功能是指心脏功能.心脏结构的心脏结构心脏代谢风险心脏代谢风险营养营养营养营养

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