辐射肠炎的高压氧疗法和临床参数:系统性审查和元分析
Yuhan Wang1, Xuhui Yang1, Minjiao Jiang2
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Frontiers in medicine
|October 27, 2025
概括
高压氧气疗法 (HBOT) 通过改善症状和减少发病率,特别是严重病例,有效治疗辐射肠炎 (RE). 标准化协议是实现可再生能源管理最佳结果的关键.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 高压医学的高压医学.
背景情况:
- 辐射肠炎 (RE) 在癌症治疗中构成了挑战,高压氧气疗法 (HBOT) 的疗效和安全性受到争议.
- 缺乏标准化的临床方案使HBOT对RE的应用复杂化.
- 这项研究系统地审查了HBOT在RE管理中的作用.
研究的目的:
- 评估关于HBOT对RE的疗效和安全性的临床证据.
- 分析RE中HBOT的治疗参数和潜在机制.
- 评估HBOT对胃肠道症状,免疫功能和RE患者炎症的影响.
主要方法:
- 在九个数据库中进行了全面的文献搜索.
- 评估了22项临床研究的数据,包括6项RCT和一项元分析.
- 分析了对RE发病率,严重程度,胃肠道症状和炎症标志物的影响.
主要成果:
- 中等质量的证据表明,HBOT显著降低了RE发生率 (OR=0.32) 和严重的RE (等级3+;OR=0.37).
- HBOT有效地改善了胃肠道症状 (MD=-1.31) 并减少了炎症标志物.
- 常见的HBOT协议包括2.0-2.5 ATA,90-120分钟,每天进行30-40次.
结论:
- HBOT可以缓解RE症状,促进粘膜的修复,并减少炎症.
- HBOT显著降低了RE的发生率,特别是严重的形式.
- 优化,个性化的HBOT协议对于最大限度地提高RE管理的有效性至关重要.
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