视神经头部在15年内发生的变化 - - 从阿特罗平治疗长期评估研究来看
Leila Sara Eppenberger1,2, Ezekiel Ze Ken Cheong1,3, Joey Chung1
1Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Ophthalmology science
|October 27, 2025
概括
这项为期15年的研究发现,儿童近视的进展与显著的视神经头部变化有关,包括增加的眼膜缩和中央视网膜血管干的鼻转移到成年期.
科学领域:
- 眼科医生 眼科 眼科
- 眼镜测量是指眼睛的测量.
- 视网膜成像 视网膜成像
背景情况:
- 氨酸治疗长期评估研究 (ATLAS) 追踪了来自氨酸治疗近视2 (ATOM2) 试验的148名近视参与者.
- 在ATOM2研究期间,参与者接受了不同度的阿特罗宾眼滴.
研究的目的:
- 为了研究视神经头部 (ONH) 从童年到成年期的纵向变化,超过15年.
- 为了确定与近视个体的ONH变化相关的因素.
主要方法:
- 一项纵向研究设计,追踪参与者超过15年.
- 使用循环自折射测量,生物测量,底部摄影和光学连贯性断层扫描 (OCT) 进行ONH分析.
- 对 fundus 照片和 OCT 图像的形态测量检查评估了诸如 parapapillary 缩 (PPA) 和 Bruch 膜开口距离等参数.
主要成果:
- 近视折射误差从基线显著增加 (-4.54 D) 到15年 (-6.88 D),轴长也在增加.
- 在15年内观察到的显著的ONH变化包括增加PPA和中央视网膜血管干 (CRVT) 位置的鼻腔移动.
- 年龄,轴长和球体等效折射被证实是与光盘变化相关的重要因素.
结论:
- 近视患者表现出渐进的ONH变化,特别是从童年到年轻成人期间增加PPA和鼻腔CRVT的转移.
- 这些发现突显了15年内近视进展中ONH的动态性质.
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