在免疫功能低下的患者中抗阿西克洛维尔抗性简单疹病毒的非典型表现:一个病例系列
Keri Allen1, Alan Wang2, Matthew A Hibdon2
1Medicine, Morsani College of Medicine, University of South Florida, Tampa, USA.
Cureus
|October 27, 2025
概括
结核性皮肤简单疹病毒 (HSV) 感染在免疫功能低下的患者中异常存在. 标准疗法可能会失败,需要长时间的抗病毒治疗和严重病例的抗药性测试.
科学领域:
- 传染性疾病 传染性疾病
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
背景情况:
- 在免疫功能低下的个体中,单纯疹病毒 (HSV) 感染可以异常表现.
- 这些感染可能会抵抗标准的抗病毒治疗,如阿西克洛维尔和福斯卡内特.
研究的目的:
- 在免疫功能低下的患者中报告三例死性皮肤HSV感染病例.
- 突出这一群体中HSV的非典型表现和治疗挑战.
主要方法:
- 一系列病例报告了三名免疫受损患者.
- 对临床表现,治疗反应和结果的审查.
主要成果:
- 这三名患者都呈现出非典型的皮肤死性HSV病变.
- 一名患有急性髓性白血病 (AML) 的患者表现出对阿西克洛维尔和福斯卡内特的折射性.
- 其他病例涉及部平细胞癌和多发性骨髓瘤患者.
结论:
- 严重免疫功能低下的患者可能需要长时间的抗病毒治疗来治疗非典型的HSV感染.
- 早期抗病毒耐药性测试和考虑辅助治疗是至关重要的.
- 需要进一步的研究来开发基于证据的协议来管理这些具有挑战性的案例.
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