治疗转变和科学影响治疗耐药抑郁症研究:一个数据驱动的视角
Yunsheng Liu1,2, Zengwei Kou3
1Cancer Center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China.
Biological psychiatry global open science
|October 27, 2025
概括
治疗耐药性抑郁症 (TRD) 研究已经从侵入性方法转向基于胺的疗法. 这种文献计量分析绘制了TRD的地图.
科学领域:
- 精神病学和神经科学 精神病学和神经科学
- 圣经计量学和科学计量学
背景情况:
- 耐治疗抑郁症 (TRD) 在精神病治疗中构成了重大挑战.
- 现有的TRD研究是分散的,需要进行全面的综合,以改善临床结果和未来的研究.
研究的目的:
- 对治疗耐药性抑郁症 (TRD) 出版物进行大规模的文献分析.
- 绘制TRD研究的演变图,确定关键贡献者,并分析随着时间的推移的主题转变.
- 为未来的TRD调查提供一个连贯的路线图.
主要方法:
- 在1974年至2025年期间,利用PubMed,Web of Science和Scopus对16198篇TRD出版物进行了文献计量分析.
- 我们使用CiteSpace,VOSviewer和Bibliometrix软件来分析出版趋势,合作和研究主题.
- 重点是确定有影响力的研究人员,机构,以及从侵入性疗法转向药理学的进步.
主要成果:
- 在TRD中确定了领先的国家,机构和研究人员.
- 关键的研究集群包括神经生物学机制 (谷氨酸,炎症) 和临床疗效.
- 观察到从侵入性技术 (2000年之前) 到基于胺的疗法 (2010年后) 的显著转变,高影响力的期刊定了智力集群.
结论:
- 图书统计分析显示,TRD研究从侵入性干预到基因胺类药物治疗等机制驱动药物治疗的演变.
- 该研究综合了碎片化的知识,为临床医生和TRD研究人员提供了路线图.
- 在了解胺的全身作用和非正规NMDA受体作用方面仍然存在差距.
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