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初级硬化性胆管炎和炎症性肠病中的感染:系统性审查和元分析
Navneet Natt1, Tyrel Jones May2, Gurpreet Malhi1
1Division of Gastroenterology, Department of Medicine, Western University, London, Ontario N6A 5C1, Canada.
Journal of the Canadian Association of Gastroenterology
|October 27, 2025
概括
患有原发性硬化性胆管炎和炎症性肠病 (PSC-IBD) 的患者比单独患有IBD的患者面临更高的感染和败血症风险. 这项研究量化了PSC-IBD患者感染风险的增加.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 临床流行病学 临床流行病学
背景情况:
- 原发性硬化性胆管炎 (PSC) 是一种胆固醇性肝病,经常与炎症性肠病 (IBD) 一起发生.
- 同时患有PSC-IBD的患者的感染风险尚未确定.
- 了解感染率和风险因素对于管理PSC-IBD患者至关重要.
研究的目的:
- 为了确定PSC-IBD患者感染的发病率.
- 为了确定与这种患者群体感染相关的风险因素.
- 为了比较PSC-IBD患者和单独患PSC或IBD患者之间的感染风险.
主要方法:
- 一个系统的审查和对MEDLINE,Embase和Cochrane索引的研究进行元分析.
- 包括的研究检查了PSC-IBD患者的感染事件率或风险因素.
- 随机效应模型被用于汇集数据并计算95%置信区间 (CI) 的几率比率 (OR).
主要成果:
- 分析包括了81项研究.
- 在PSC-IBD患者中,所有原因感染的聚合事件率为25.1%.
- 与仅患有IBD的患者相比,PSC-IBD患者的全因感染 (OR 3.67),败血症 (OR 3.35) 和与感染相关的死亡率 (OR 11.25) 的几率明显更高.
结论:
- 患有PSC-IBD的患者具有显著增加所有原因感染的风险.
- 与仅IBD患者相比,PSC-IBD患者的败血症和与感染有关的死亡率的风险也显著增加.
- 这些发现凸显了需要在PSC-IBD中保持警的感染监测和管理.
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