在ST升高心肌梗塞的穿皮冠状动脉干预期间,安德克萨内特α诱导的肝素耐药性:一个病例报告
Satoru Sasaki1, Daisuke Matsumoto1, Ryo Takeshige1
1Division of Cardiovascular Medicine, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, Osaka 533-0024, Japan.
European heart journal. Case reports
|October 27, 2025
概括
安德克萨内特阿尔法可以引起肝素耐药性,使皮肤冠状动脉干预 (PCI) 等紧急程序复杂化. 及时识别这种副作用对于紧急干预期间的患者结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 安德克萨内特阿尔法可逆转直接口服的XA因子抑制剂,但可能导致肝素耐药性.
- 这种耐药性可能会使紧急手术,如穿皮冠状动脉干预 (PCI) 复杂化.
- 这种现象未被充分认识到,并构成了治疗挑战.
研究的目的:
- 突出在新出现的PCI期间,安德克萨尼特阿尔法诱导的肝素耐药性的挑战.
- 为了强调快速识别这种并发症的重要性.
主要方法:
- 一个82岁的男性接受edoxaban治疗,出现骨折和血瘤的病例报告.
- 用安德克萨内特阿尔法治疗抗凝血逆转.
- 发展ST段升高心肌梗塞 (STEMI) 和新出现的PCI.
- 在PCI期间评估肝素耐药性.
主要成果:
- 患者患上了STEMI,需要紧急的PCI.
- 观察到严重的肝素耐药性,延迟了抗凝血作用.
- 尽管成功进行了再血管,但患者经历了并发症和死亡.
结论:
- 安德克萨尼特阿尔法诱导的肝素耐药性可以显著复杂化新出现的PCI.
- 快速识别肝素耐药性对于有效的抗凝药和最佳结果至关重要.
- 这一案例强调了临床医生管理需要在安德克萨尼特阿尔法剂后需要紧急手术的患者的需要.
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