慢性肺病中的肠道微生物组失调:系统性审查和元分析
Juan Pan1, Yanjie Zhang1, Songlin Qiu1
1Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Frontiers in cellular and infection microbiology
|October 27, 2025
概括
慢性肺病 (CLD) 改变了肠道微生物群,慢性阻塞性肺病 (COPD) 减少了多样性和较低的益生菌水平. 这些发现表明益生菌可能提供新的COPD治疗途径.
科学领域:
- 微生物组研究 微生物组研究
- 肺部医学 肺部医学
- 肠-肺轴 肠-肺轴 是一个
背景情况:
- 新出现的证据表明,肠肺轴与肺病病原发生有关.
- 肠道微生物组成和慢性肺病 (CLD) 之间的特定关系需要进一步阐明.
研究的目的:
- 系统地调查诊断为CLD的患者肠道微生物组的变化.
- 分析肠道微生物多样性的变化和CLD群体中的特定细菌丰度.
主要方法:
- 在多个数据库 (PubMed,科学网,Embase等) 进行全面的文献搜索. 在2024年8月之前.
- 包括27项研究,重点关注慢性肺炎患者的肠道菌群,包括慢性阻塞性肺病 (COPD) 和喘.
- 使用随机效应模型对α-多样性,β-多样性和相对丰度变化的元分析;通过埃格尔测试评估出版偏差.
主要成果:
- 与健康对照组 (SMD = -0.38) 相比,在COPD患者中观察到较低的α-多样性 (香农指数).
- 在COPD中,增加了Bacteroides丰富度 (SMD = 0.76) 和减少了Bifidobacterium (SMD = -0.88) 和乳杆菌 (SMD = -0.73).
- 在喘患者和健康对照人群之间没有发现显著的多样性差异.
结论:
- 慢性肺炎患者的肠道微生物群表现出显著的不平衡,其特点是有益细菌 (益生菌) 的丰度较低.
- 向益生菌需要进一步研究,作为一种潜在的COPD治疗策略.
相关概念视频
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.1K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.1K
01:20COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
3.5K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.5K
01:22Chronic Obstructive Pulmonary Disease
2.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.2K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.5K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.5K