病例报告:在患有骨髓增殖障碍的患者中对基尿素的晚期过敏反应
Navkirat Kahlon1, Sujatha Baddam2, Harinderjeet Kaur3
1Department of Medical Oncology, Mass General Cancer Center at Wentworth-Douglass Hospital, Dover, New Hampshire, USA.
Case reports in hematology
|October 27, 2025
概括
氧尿素是骨髓纤维化症的关键治疗方法,可以引起罕见的过敏反应. 这一案例表明,停用基尿素和切换到ruxolitinib可以缓解症状,强调需要谨慎管理.
科学领域:
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 氧尿素是一种用于骨髓增殖性新生体的标准治疗方法,如骨髓纤维化.
- 对酸的过敏反应很少发生,但可能需要改变治疗方法.
研究的目的:
- 描述一个患有早期骨髓纤维化症的患者在氧尿素诱导过敏症的病例.
- 强调识别和管理氧尿素过敏的重要性.
主要方法:
- 一名患有JAK2 V617F阳性髓纤维化症的患者接受了氧尿素的治疗.
- 患者经历了反复出现的过敏反应后,氧尿素重新挑战.
- 在停用氧尿素后,治疗被切换为 ruxolitinib.
主要成果:
- 患者出现了延迟过敏症状,包括发烧,寒和疲劳.
- 症状在每次基尿素重新挑战后迅速复发,即使在交替日剂量后.
- 停用氧尿素后,症状的永久解决得到了.
结论:
- 基尿素过敏可能发生在骨髓纤维化患者中,需要谨慎监测.
- 可能需要停止基尿素治疗,并转向像鲁克索利提尼布这样的替代疗法.
- 及时识别和管理对于优化素尿素治疗骨髓纤维化患者的治疗结果至关重要.
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