一个新的有机 Schiff 基- (IV) 综合体:合成,结构洞察力 (XRD/对接) 和抗菌活性
Yasmin M S Jamil1, Fathi M Al-Azab1, Ahmed N Alhakimi2
1Chemistry Department, Faculty of Science, Sana'a University, Sana'a 12231, Yemen.
ACS omega
|October 27, 2025
概括
一种新的有机基希夫基联体及其 (IV) 复合物被合成和特征化. 这两种化合物都表现出抗菌活性,对大肠杆菌 (Escherichia coli) 观察到的最大抑制.
科学领域:
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 药用化学 医学化学
背景情况:
- 希夫基是协调化学中的多功能连接体.
- 有机化合物表现出多样化的生物活性.
- 复合物正在探索各种应用,包括抗菌用途.
研究的目的:
- 合成和表征一种新的有机 Schiff 基联体 (EAMDPP) 和其 (IV) 复合物.
- 通过分子对接来研究合成化合物与细菌蛋白质的结合模式.
- 评估连接体及其复合体对所选细菌菌株的抗菌活性.
主要方法:
- 合成有机基希夫基联体 (EAMDPP) 和其Ti(IV) 复合物.
- 使用元素分析,IR,UV-vis,NMR和XRD进行表征.
- 分子对接研究针对金黄色葡萄球菌,杆菌 pyogenes 和大肠杆菌.
- 通过抑制试验进行抗菌活性测试.
主要成果:
- 成功合成并对EAMDPP配体及其Ti(IV) 复合体进行了完整的表征.
- 分子对接揭示了与标蛋白的潜在结合相互作用.
- 无论是EAMDPP还是其Ti(IV) 复合物都表现出抗菌活性.
- 对于这两种化合物来说,在300μg/mL时观察到对大肠杆菌的最高抑制.
结论:
- 合成的有机基希夫基联体及其复合物是具有潜在生物应用的新型化合物.
- 该研究提供了对这些化合物的分子相互作用和抗菌功效的见解.
- 进一步的研究可以探索优化这些化合物以增强抗微生物特性.
更多相关视频
08:46Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
Published on: November 22, 2016
8.2K
07:20Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
14.4K
相关概念视频
02:42Valence Bond Theory
11.2K
Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
11.2K
02:46Crystal Field Theory - Tetrahedral and Square Planar Complexes
48.1K
Tetrahedral Complexes
Crystal field theory (CFT) is applicable to molecules in geometries other than octahedral. In octahedral complexes, the lobes of the dx2−y2 and dz2 orbitals point directly at the ligands. For tetrahedral complexes, the d orbitals remain in place, but with only four ligands located between the axes. None of the orbitals points directly at the tetrahedral ligands. However, the dx2−y2 and dz2 orbitals (along the Cartesian axes) overlap with the ligands less than the dxy,...
Crystal field theory (CFT) is applicable to molecules in geometries other than octahedral. In octahedral complexes, the lobes of the dx2−y2 and dz2 orbitals point directly at the ligands. For tetrahedral complexes, the d orbitals remain in place, but with only four ligands located between the axes. None of the orbitals points directly at the tetrahedral ligands. However, the dx2−y2 and dz2 orbitals (along the Cartesian axes) overlap with the ligands less than the dxy,...
48.1K
02:52Stereoisomerism
13.8K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
13.8K