生物活性Cr(III),Co(II) 和Mn(II) 复合物与N'((3-Hydroxynaphthalen-2-yl) methylene) picolinohydrazide:结构,计算和生物学研究
Yasmeen G Abou El-Reash1, Saja Abdulrahman Althobaiti2, Sahar Abdalla1
1Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.
ACS omega
|October 27, 2025
概括
新型生物活性金属复合物Cr,Co和Mn使用希夫基联结体进行了合成. 这些复合物显示出有前途的DNA降解,抗菌和抗癌活性,复合物对癌症细胞系表现出显著的有效性.
科学领域:
- 协调化学 协调化学
- 生物有机化学 生物有机化学
- 材料科学 材料科学 材料科学
背景情况:
- 希夫基联结体为金属离子提供了多功能协调点.
- 金属复合物被用于各种生物应用,包括抗微生物和抗癌疗法.
- 了解金属-连接体相互作用对于设计有效的治疗剂至关重要.
研究的目的:
- 使用希夫基联结体合成和表征新型生物活性金属复合物Cr (III),Co (II) 和Mn (II).
- 研究这些复合物的协调行为,稳定性和生物活动 (DNA降解,抗菌,抗癌).
- 用计算方法阐明配体-受体相互作用.
主要方法:
- 通过直接的金属-连接体反应合成金属复合物.
- 使用光谱 (FT-IR,UV-Vis,1H NMR,MS),PXRD,磁感应和热分析进行了表征.
- 生物评估包括DNA降解分析,MIC确定,细胞毒性测试和分子对接.
主要成果:
- 综合体呈现出不同的几何形状 (四面体为Co(II) /Mn(II),八面体为Cr(III)).
- 在非自发分解路径下观察到高热稳定性.
- 显著的核酶类活性 (Co2复合物),强烈的抗菌活性 (Mn2复合物) 和高抗癌疗效 (Co2复合物) 已被证明.
- 分子对接揭示了与DNA目标的强烈非共价相互作用.
结论:
- 合成的希夫基金属复合物具有显著的生物潜力.
- 复合物特别有望作为抗癌剂.
- 对这些复合物的进一步研究可能会导致新的治疗策略.
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