在亚急性甲状腺炎中概述肠道微生物组动态:对病变发生,诊断和治疗的影响
Jiayun Li1,2, Jiasheng Ju3, Qian Xu1
1Department of Endocrinology, 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Kunming, Yunnan, 650032, China.
亚急性甲状腺炎 (SAT) 与肠道微生物组的变化有关,特定细菌增加或减少. 普雷尼索隆治疗部分恢复了肠道细菌,这表明它在SAT发育和反应中发挥了作用.
科学领域:
- 微生物学 微生物学
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
背景情况:
- 亚急性甲状腺炎 (SAT) 是一种炎症性甲状腺疾病,病因不明.
- 肠道微生物群在免疫系统调节中起着至关重要的作用,并与各种自身免疫性疾病有关.
研究的目的:
- 在新诊断的SAT患者中描述肠道微生物组的变化.
- 识别与SAT相关的微生物特征及其治疗反应.
主要方法:
- 来自20名SAT患者和20名健康对照者的便样本的16S核糖体RNA基因测序.
- 生物信息学分析微生物的α/β多样性,分类构成和差异性丰度.
- 研究肠道微生物组与临床参数之间的相关性.
主要成果:
- 在SAT患者中,肠道微生物群发生变化,埃舍里希亚-希格拉菌,比菲多细菌,阿克尔曼西亚,维龙氏菌和链球菌的增加.
- 在SAT患者中观察到,Bacteroidetes,Faecalibacterium,Prevotella,Roseburia和Ruminococcus的丰富性减少. 在SAT患者中观察到,Bacteroidetes,Faecalibacterium,Prevotella,Roseburia和Ruminococcus的丰富性减少. 在SAT患者中观察到,Bacteroidetes,Faecalibacterium,Prevotella,Roseburia和Ruminococcus的丰富性减少.
- 普雷迪尼索隆治疗部分使肠道微生物群正常化,乳酸菌,乳酸菌,乳酸菌reuteri和Prevotella被确定为治疗后的生物标志物.
结论:
- SAT与明显的肠道微生物组变化有关.
- 这些变化在接受普雷迪尼索隆治疗后是部分可逆的.
- 肠道微生物组可能在SAT病原和治疗反应中发挥作用.
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