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基于脂质的注射纳米药物的体外和体内相关性:从溶解到蛋白质冠状

Huan Wang¹, Xiying Wu², Junji Wang¹

¹Department of Pharmaceutical Sciences, School of Pharmacy, Naval Medical University, Shanghai, China.

Materials today. Bio

|October 27, 2025

概括

基于脂质的纳米药物 (LBNMs) 对药物输送具有前景,但预测其体内性能具有挑战性. 将蛋白质冠状分析纳入体外-体内相关性 (IVIVC) 模型对于准确的预测至关重要.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
药理学药理学是一个学科.

背景情况:

基于脂质的纳米药物 (LBNMs) 提供先进的药物递送能力,提高生物可用性和精度.
由于复杂的生物相互作用,对LBNMs建立可靠的体外-体内相关性 (IVIVC) 受到阻碍.
传统的IVIVC模型难以复制生理动态,导致LBNM性能预测的差异.

研究的目的:

对LBNMs的当前IVIVC模型进行审查.
要突出蛋白质冠状体在LBNM行为中的作用.
倡导将蛋白质冠状分析纳入LBNM IVIVC框架.

主要方法:

对LBNMs的IVIVC模型进行系统的文献综述.
分析蛋白冠状形成及其对纳米医学命运的影响.
评估新兴的战略,以弥合体外和体内数据.

主要成果:

蛋白冠状形成显著影响LBNM与生物系统的相互作用,影响免疫反应和生物分布.
当前的IVIVC模型经常忽略蛋白质冠状病毒效应,导致不准确的预测.
结合蛋白质冠状分析的先进模型显示了改善相关性的潜力.

结论:

蛋白冠状病毒分析对于开发LBNM准确的IVIVC模型至关重要.
将蛋白质冠状体征纳入LBNM研究对于成功的临床转化至关重要.
未来的IVIVC策略必须考虑纳米粒子-生物界面上的生物分子相互作用.

关键词:

解散解散解散是一个过程.在体外-体内相对应的相关性.在体内交付过程中的 in vivo 交付过程.基于脂质的纳米药物蛋白质冠冕是一种蛋白质冠冕.

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