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多功能纳米平台用于瘤微环境重塑:朝着精确和智能癌症治疗的方向

Xiangying Deng¹, Xinglong Liu^2,3, Lin Zhao^2,3

¹Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.

Materials today. Bio

|October 27, 2025

概括

纳米技术提供了一种有前途的策略来重塑瘤微环境 (TME),克服癌症治疗耐药性. 多功能纳米平台可以准TME障碍,提高个性化癌症治疗的治疗效果.

科学领域:

在瘤学瘤学.
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

瘤异质性和治疗耐药性是癌症治疗的主要挑战.
瘤微环境 (TME),以缺氧,酸性,免疫抑制和细胞外矩阵 (ECM) 重塑为特征,有助于应对这些挑战.
调节TME是一种有前途的策略,可以提高癌症治疗的有效性.

研究的目的:

审查纳米技术驱动的TME重塑用于癌症治疗的最新进展.
突出针对TME的多功能纳米平台的设计策略.
讨论开发智能,以患者为中心的癌症治疗系统的未来机遇和挑战.

主要方法:

利用无机,有机和混合纳米载体进行向的TME调制.
利用增强的透性和保留 (EPR) 效应,表面连接体工程,以及用于药物和基因传递的响应元件.
将纳米平台与光热/光动力疗法,免疫疗法和代谢重编程等疗法集成.

主要成果:

纳米平台可以使瘤血管正常化,逆转缺氧,调节免疫抑制,并降低ECM.
这些行为使瘤对传统和新兴疗法的敏感.
人工智能引导的精密传输和智能纳米材料正在为个性化癌症管理提供治疗生态系统.

结论:

纳米技术为TME调制提供了强大的工具,克服了癌症治疗中的关键障碍.
多功能纳米平台为全面的多模式癌症治疗提供了一条途径.
人工智能和纳米材料的整合有望实现动态,个性化的癌症管理策略.

关键词:

人工智能治疗生态系统免疫治疗是一种免疫疗法.纳米医学是一种纳米医学.刺激响应性传递是对刺激的反应.瘤微环境是一个微环境.

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