在患有缺食症的患者中,顶部食道和喉压力的峰值之间的相关性
Molly A Knigge1, Sarah P Rosen2, Timothy M McCulloch2
1University of Wisconsin - Madison Madison Wisconsin USA.
Laryngoscope investigative otolaryngology
|October 27, 2025
概括
上胃关节 (UES) 峰值压力与健康个体的喉压力相关. 这种关系在患有食障碍的患者中失去了,这表明其他因素影响了UES功能.
科学领域:
- 胃肠病学 胃肠病学
- 吞生理学的吞生理学
- 高分辨率的测量力度计
背景情况:
- 上部食道 (UES) 在管理上部气消化道方面发挥着至关重要的作用.
- 之前的研究已经确定了在正常吞过程中UES休息和nadir压力的重要性.
- 在高分辨率测量仪 (HRM) 上观察到的高振幅UES峰值压力,需要进一步表征.
研究的目的:
- 调查UES峰值压力和喉峰值压力在喉和舌头底部区域之间的关系.
- 为了比较患有食障碍的患者与健康对照者的这些关系.
主要方法:
- 喉高分辨率计量 (HRM) 对63名患有失消的成年患者进行了测量.
- 记录了喉区域,舌头底部区域和UES的峰值压力.
- 数据与年龄和性别匹配的健康对照进行了比较.
主要成果:
- 在患有消化障碍的患者中,UES峰值压力与喉或舌头底部区域压力没有显著相关.
- 相反,在健康受试者中,UES峰值压力与喉 (r=0.525,p<0.001) 和舌头底部 (r=0.415,p=0.001) 区域压力都有正相关性.
- 在患者和对照组中,观察到白喉和舌头底部区域压力之间存在显著的相关性.
结论:
- 喉和UES峰值压力在健康个体中是相互依存的.
- 缺少这种相关性在食障碍患者表明,UES峰值压力可能会受到超出喉收缩活动和玻鲁斯相关的感觉反的因素的影响.
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