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整合转录基因组和基因组研究,以确定与牛结核相关的表达定量特征位点

Gerard Badia-Bringué¹, Marta Alonso-Hearn¹

¹Department of Animal Health, NEIKER-Basque Institute of Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, Spain.

Frontiers in veterinary science

|October 27, 2025

概括

了解宿主对Mycobacterium avium亚种的反应的遗传基础. 结核病 (MAP) 是至关重要的. 本综述侧重于cis表达量性特征位点 (cis-eQTLs),以深入了解牛甲状腺结核病 (PTB) 耐药性.

科学领域:

遗传学是一个遗传学.
免疫学免疫学免疫学
兽医科学兽医科学兽医科学

背景情况:

全基因组关联研究 (GWAS) 确定宿主对Mycobacterium avium亚种的反应的遗传标记. 部分结核病 (MAP).
来自GWAS的许多显著的单核酸多态 (SNP) 存在于非编码区域,使功能解释和基因链接复杂化.
有限的cis表达量性特征位点 (cis-eQTLs) 具有对牛结核病 (PTB) 易感性或耐药性的特征.

研究的目的:

审查目前的研究,整合转录和基因组数据,以了解MAP感染耐药性/易感性的遗传结构.
突出在牛甲结核病中cis-eQTLs的鉴定和功能解释.
讨论cis-eQTL在育种和遗传技术中的实际应用.

主要方法:

综合转录和基因组数据的现有文献的审查.
专注于cis-eQTLs的识别和功能分析.
讨论与PTB相关的基因表达变异性中的cis-eQTL作用.

主要成果:

大多数GWAS识别的SNP都位于非编码区域,这给功能相关性带来了挑战.
Cis-eQTLs提供了一个将遗传变异与影响PTB易感性的基因表达变化联系起来的机制.
最近的研究开始通过综合数据方法揭示基因架构.

结论:

Cis-eQTLs是理解牛结核病耐药性的功能遗传基础的关键.
整合转录和基因组数据对于识别和解释cis-eQTLs至关重要.
验证的cis-eQTL在基因组选择,查和基因组编辑中具有潜在的应用,用于PTB控制.

关键词:

表示定量特征位置 (eQTL)基因表达的基因表达方式基因组学就是基因组学.结核病是一种结核病.翻译学翻译学翻译学翻译学

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