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Updated: Jan 14, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells
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在PAF1和ENL/AF9 YEATS抑制之间发生的化学遗传相互作用

Paige A Barta1, Leopold Garnar-Wortzel1, Timothy R Bishop1

  • 1Department of Chemistry, The Scripps Research Institute La Jolla CA USA michaelerb@scripps.edu.

RSC chemical biology
|October 27, 2025
PubMed
概括

在白血病中抑制ENL/AF9 YEATS域不仅仅依赖于降低目标基因的调节. 抗药机制,如PAF1突变,尽管药物反应不同,但显示出共享的转录效应.

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