免疫的先天性错误中的过敏表现:系统的范围审查
Lars Marbet1, Esther Gujer1, Marlene H Münger1
1Division of Immunology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Frontiers in immunology
|October 27, 2025
概括
过敏性疾病在患有天生的免疫错误 (IEI) 的患者中很常见. 这篇评论强调了过敏.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
- 过敏和免疫学 过敏和免疫学
背景情况:
- 过敏性疾病经常出现在具有先天性免疫错误 (IEI) 的个体中.
- 导致IEI的潜在单一性疾病的诊断可能会延迟,影响及时治疗.
- IEI与过敏状况之间的关联需要进一步探索现有文献.
研究的目的:
- 从已发表的文献中创建IEI案例的综合数据库.
- 分析IEI患者过敏疾病的流行率和特征.
- 评估过敏状况与其他免疫失调之间的关系.
主要方法:
- 进行了相关科学文献的系统范围审查.
- 包括738篇文章,报告了3050名患有天生的免疫错误的个体患者.
主要成果:
- 7.4%的患者 (n=226) 已记录过敏,其中食物过敏是最常见的 (76.1%).
- 过敏状况与各种IEI亚组有关,但与其他免疫失调相关的显著例外.
- 性疾病 (食物过敏,过敏性鼻炎,喘,湿疹) 的总流行率为26.9% (n=821).
结论:
- 在IEI中,过敏性疾病是免疫失调的显著表现.
- 这些发现旨在提高IEI的临床医生和研究人员对过敏的认识.
- 本综述是改善IEI相关过敏的诊断和管理的资源.
相关概念视频
Allergic Reactions
32.0K
Overview
32.0K
Allergic Drug Reactions
1.3K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.3K
Hypersensitivities
7.2K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.2K
Cross-reactivity
32.8K
Overview
32.8K
Asthma: Pathogenesis and Management
1.2K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K
Asthma-II: Pathophysiology and Classification
4.1K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.1K


