帕金森病免疫疗法的研究:通过多个数据库进行文献计量分析
Xinxing Fei1, Shiqi Wang2,3, Jiayi Song4,5
1Department of Psychiatry, Chengdu Eighth People's Hospital (Geriatric Hospital of Chengdu Medical College), Chengdu, China.
Frontiers in immunology
|October 27, 2025
概括
本文献分析绘制了帕金森病 (PD) 免疫治疗的研究格局,揭示了关键趋势和合作. 未来的研究应该专注于临床试验,用于PD的精确免疫干预.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 图书统计学 图书统计学
背景情况:
- 帕金森病 (PD) 的特点是神经退行,α-synuclein聚合和神经炎症.
- 尽管PD免疫疗法研究取得了快速进展,但缺乏全面的文献分析.
研究的目的:
- 为了对帕金森病免疫疗法研究进行参考资料分析.
- 确定PD免疫治疗中的研究趋势,关键贡献者和新兴主题.
主要方法:
- 在 Web of Science 核心集合和 Scopus 中进行文献搜索.
- 使用Bibliometrix软件进行图书统计分析.
- 从PubMed和试验注册表中总结临床试验特征.
主要成果:
- 分析了来自488个来源的890份文件,涉及1,483个机构和63个国家的3,804名研究人员.
- 确定"帕金森病"",免疫疗法"和"α-synuclein"作为频繁的关键词.
- 地图显示了两个主要的研究集群,并包括了8项专注于活性免疫疗法和向抗体的临床试验.
结论:
- 在PD免疫疗法领域显示出显著的发展潜力.
- 目前的研究强调了解病理机制和开发新的治疗策略.
- 未来的方向包括精确的免疫干预和大规模随机对照试验,以提高临床翻译.
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