调查压缩模拟器和旋转压力机之间的模拟填充机制的差异
Ben Kohlhaas1,2, Jan Henrik Finke1,2
1Institute for Particle Technology, Technische Universität Braunschweig, Volkmaroder Straße 5, 38104 Braunschweig, Germany.
International journal of pharmaceutics: X
|October 27, 2025
概括
在压缩模拟器上进行模具填充的表征显示,吸气驱动的机制与旋转压力机不同. 了解这些差异对于准确的平板电脑制造规模扩大至关重要.
科学领域:
- 制药科学 制药科学
- 机械工程 机械工程
- 材料科学 材料科学 材料科学
背景情况:
- 模具填充是药片制造的关键步骤,影响药片的重量,强度和缺陷.
- 现有的研究主要是旋转压力机上的模压填充模型,对压缩模拟器的研究有限.
研究的目的:
- 在压缩模拟器上描述模具填充行为.
- 为了比较压缩模拟器和实验室规模的旋转压力机之间的模拟填充动态.
- 调查工艺参数,机器几何和材料特性对模具填充的影响.
主要方法:
- 模具填充在压缩模拟器和旋转压力机上的实验性表征.
- 在模具填充过程中基于物理的压差计算.
- 在不同条件下对填充机制进行比较分析.
主要成果:
- 在压缩模拟器上,由于几何和较高的较低冲击速度,吸入填充更强烈,从而降低了速度的重要性.
- 旋转压力机需要轮旋转以获得足够的粉末流量,特别是在高速时,由于填充时间更短.
- 替代填充凸轮几何学可以降低吸气压力,潜在地降低充填产量对于流动不良的材料.
结论:
- 已经建立了对压缩模拟器上模具填充机制的全面理解.
- 比较数据为从压缩模拟器到旋转压力机的理性规模转移模型提供了基础.
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