增加的LOXL2有助于在带有鼻的eosinophilic慢性鼻炎的组织重塑
Changcan Jiang1, Xiaoqiong Wang1, Ruoqi Li1
1Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
溶氧化酶样蛋白2 (LOXL2) 在带鼻息肉的eosinophilic慢性鼻炎 (eCRSwNP) 中被上调,通过TGF-β1 / Smad信号驱动组织重塑. 这种蛋白质显示了eCRSwNP的诊断潜力.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 蛋白质组学是指蛋白质组学.
- 分子生物学分子生物学
背景情况:
- 带有鼻的eosinophilic慢性鼻炎 (eCRSwNP) 具有显著的组织重塑的特点.
- 驱动这种重塑的潜在分子机制尚未完全理解.
研究的目的:
- 在CcRSwNP中确定参与组织重塑的关键调节蛋白.
- 调查基氧化酶样蛋白2 (LOXL2) 在eCRSwNP病原发生中的作用.
主要方法:
- 从CRSwNP患者,非eosinophilic CRSwNP患者和健康对照患者的鼻子组织的蛋白质组分析.
- 使用西式涂抹,免疫光和qRT-PCR的候选蛋白质的验证.
- 使用人类鼻上皮细胞 (HNEC) 进行体外研究,以探索功能机制.
主要成果:
- 在CcRSwNP组织中,LOXL2的调节显著上升,并且与乙氨基细胞透相关.
- LOXL2表达与表皮层-介质细胞过渡 (EMT) 标记物相关.
- 在体外,LOXL2诱导了HNEC中的TGF-β1和EMT标记物,由TGF-β1/Smad通路介导.
结论:
- LOXL2 是 eCRSwNP 中的一种疾病特异性蛋白质,与乙酸性炎症和组织重塑有关.
- 在CcRSwNP中,LOXL2促进EMT,可能通过TGF-β1/Smad信号通路.
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