活跃癌症与COVID-19的门诊患者中血栓和心血管结果的风险之间的关联: A CORONA-VTE网络分析
Bridget McGonagle1,2, Christie Greason1,2, Darsiya Krishnathasan1,2
1Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
TH open : companion journal to thrombosis and haemostasis
|October 27, 2025
概括
患有COVID-19的活跃癌症患者患有血栓事件的风险明显更高. 这凸显了在疫情期间对癌症患者进行仔细监测和管理的必要性.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 冠状病毒疾病2019 (COVID-19) 和活跃癌症独立地增加了血栓和心血管事件的风险.
- 有限的数据存在于两个条件的非住院患者的综合风险.
研究的目的:
- 追溯调查COVID-19的门诊患者中活跃癌症和血栓和心血管结果之间的关联.
主要方法:
- 使用了来自美国CORONA-VTE网络注册表 (10,420名患者) 的数据.
- 被定义的活跃癌症是过去一年内最近的诊断或治疗 (不包括非黑色素瘤皮肤癌).
- 判决结果包括血栓栓塞和主要不良心血管事件在COVID-19诊断后90天内.
主要成果:
- 在6576名门诊患者中,166人患有活跃的癌症.
- 癌症患者的90天累计血栓栓塞发生率为4.2%,非癌症患者的1.2% (HR:3.65).
- 90天内心血管事件的累计发病率在癌症患者中为5.4%,而非癌症患者中为1.9% (HR:2.97).
- 调整后的分析显示,非住院癌症患者的血栓结局风险增加 (HR:2.48),但心血管结局风险没有增加 (HR:1.76).
结论:
- 与没有癌症的患者相比,COVID-19和活跃癌症的非住院门诊患者面临血栓事件的风险增加.
相关概念视频
Cancer Survival Analysis
645
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
645
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Rous Sarcoma Virus (RSV) and Cancer
6.2K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.2K
Psychoneuroimmunology: Diabetes and Cancer
432
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
432
What is Cancer?
13.9K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
13.9K
mTOR Signaling and Cancer Progression
4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.6K


