用布利祖马布单一治疗高级上皮层癌的第二阶段研究
Brenda Chahla1, Bettzy Stephen2, Juhee Song3
1Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Journal of immunotherapy and precision oncology
|October 27, 2025
概括
布利祖马布单一治疗对晚期上皮层癌 (ACC) 具有前景,在患有这种罕见癌症的患者中提供持久的反应和可管理的安全性.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 临床试验 临床试验
背景情况:
- 皮上腺癌 (ACC) 是一种罕见的内分泌恶性瘤,治疗选择有限.
- 在ACC中,化疗反应往往低于最佳,这凸显了对新型治疗策略的需求.
- 免疫疗法在ACC管理中的潜力是正在积极研究的一个领域.
研究的目的:
- 评估pembrolizumab作为单剂疗法的疗效和安全性,用于晚期ACC患者.
- 确定27周的非进展率作为主要终点.
- 评估不良事件和其他二次疗效结果.
主要方法:
- 进行了一项由研究人员发起的,开放标签的,第二阶段篮子临床试验.
- 23名患有晚期ACC的患者接受了pembrolizumab (200毫克静脉注射每3周一次).
- 在 pembrolizumab 开始之前,先前的治疗,包括米托坦,都已停止. 使用免疫相关的标准来评估反应.
主要成果:
- 在20名可评估患者中,30%的患者在27周内实现了非进展率.
- 四名患者 (20%) 出现了部分反应,平均持续时间为17.6个月.
- 中位数无进展生存期为4.0个月,中位数总生存期为15.5个月. 三个与治疗相关的不良事件是3级或更高的.
结论:
- 单剂布罗利祖马布在先进的ACC中显示出持久反应的潜力.
- 该疗法在研究的患者队列中表现出可管理的安全性.
- 布罗利祖马布代表了高级上腺皮层癌的有前途的治疗选择.
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