法里西马布治疗耐火性神经血管与年龄相关的黄斑退化:来自印度的回顾性现实世界的证据
Rupak K Biswas1, Jay U Sheth2, Vaibhav Shrivastava3
1Department of Retina Services, Netralayam - The Superspeciality Eye Care Centre, Kolkata, India.
Clinical ophthalmology (Auckland, N.Z.)
|October 27, 2025
概括
在印度患者中,法里西马布显著改善了视力和减少了视网膜液,这些患者患有耐火性新血管与年龄相关的黄斑变性 (nAMD). 这项研究支持法里西马布作为nAMD的有效治疗选择,大多数患者在六个月内需要两次或更少的注射.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 在维护视觉功能方面构成了重大挑战.
- 现有的抗VEGF疗法需要频繁的管理,影响患者的遵守和医疗保健成本.
- 耐火性nAMD病例需要替代或优化治疗策略.
研究的目的:
- 评估法里西马布在印度耐火性nAMD患者中的实际解剖和功能结果.
- 评估法里西马布在六个月的时间内在不同患者队列中的疗效.
- 为了确定与法里西马布相关的治疗负担,在这个特定的患者群体.
主要方法:
- 追溯性,多中心研究涉及24只眼睛,耐火性nAMD转换为faricimab.
- 在前三个月内每月评估的预产后 (PRN) 剂量方案.
- 评价最佳校正的视力敏度 (BCVA),中央叶厚度 (CFT) 和视网膜液 (IRF,SRF,PED).
主要成果:
- 在第6个月 (P≤0.0003) 中,BCVA平均值从0.66到0.27 logMAR显著改善.
- 到第6个月,平均CFT从471.1μm减少到209.4μm (P<0.0001).
- 流体分辨率的高率:SRF (90.9%),IRF (87.5%) 和完整的流体分辨率 (83.3%).
结论:
- 法里西马布在耐火性nAMD中表现出强大的视觉效益和显著的解剖学改善.
- 治疗显示了有利的注射频率,超过一半的眼睛需要≤2次注射.
- 法里西马布是耐火性nAMD的有希望的切换疗法,需要进一步研究长期结果.
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