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Updated: Jan 14, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

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预测抗体和T细胞受体互补性决定区域的结构灵活性

Fabian C Spoendlin1, Monica L Fernández-Quintero2, Sai S R Raghavan2

  • 1Department of Statistics, University of Oxford, Oxford, UK.

Nature machine intelligence
|October 27, 2025
PubMed
概括

研究人员开发了ITsFlexible,这是一种深度学习工具,用于预测抗体互补性确定区域 (CDR) 中的蛋白质结构灵活性. 该工具准确地将CDR循环分类为刚性或柔性,从而推进了抗原相互作用研究.

关键词:
生物制剂 生物制剂 生物制剂结构生物学是结构生物学.

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