Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

20.5K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
20.5K
RNA-seq03:21

RNA-seq

11.7K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
11.7K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.5K
3.5K
Protein Networks02:26

Protein Networks

4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
Protein Networks02:26

Protein Networks

2.8K
2.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Pharyngeal Microenvironment Associated with Human Rhinovirus Infection in Children: Insights from Metatranscriptomic Sequencing.

NPJ biofilms and microbiomes·2026
Same author

Ratiometric Fluorescence Biosensor of Allosteric Ag Nanoclusters by G-Quadruplex-Aided Displacement Amplification.

ACS sensors·2026
Same author

Chiral graviton modes in fermionic fractional Chern insulators.

Reports on progress in physics. Physical Society (Great Britain)·2026
Same author

Artificial intelligence for detecting fetal orofacial clefts and advancing medical education.

Nature communications·2026
Same author

Lung motion estimation from 4D CT using structure-tensor-guided finite-element digital volume correlation.

Physics in medicine and biology·2026
Same author

Bivariate Cooperator-Catalyzed Hairpin Assembly for Amplifying Conformation-Guided Label-Free Ratiometric Fluorescence Biosensing.

Analytical chemistry·2026

相关实验视频

Updated: Jan 14, 2026

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease
04:22

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

1.3K

ncFN:基于全球和异质生物分子网络的全面非编码RNA功能注释框架.

Min Long1, Haizhou Liu2,3, Mengqin Yuan1

  • 1Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, Jiangsu, 211106, China.

Non-coding RNA research
|October 27, 2025
PubMed
概括

我们开发了ncFN,这是使用全球生物分子网络对非编码RNA (ncRNA) 函数进行注释的新框架. 该工具准确地识别了微RNA,长非编码RNA和圆形RNA的功能.

关键词:
生物网络是生物网络.功能注释功能注释分子相互作用分子相互作用.随机步行与重新启动.这是一个ncRNARNA.

更多相关视频

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
08:09

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

20.5K
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.2K

相关实验视频

Last Updated: Jan 14, 2026

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease
04:22

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

1.3K
Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
08:09

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

20.5K
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.2K

科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 分子生物学分子生物学

背景情况:

  • 非编码RNAs (ncRNAs) 在生物过程中起着至关重要的作用,但它们的功能在很大程度上仍未被描述.
  • 现有的方法往往侧重于单个ncRNA类型,限制了全面的功能注释.

研究的目的:

  • 开发ncFN,一个新的和全面的框架,用于ncRNA功能注释.
  • 将不同的ncRNA类型 (miRNA,lncRNA,circRNA) 整合到统一的分析方法中.

主要方法:

  • 构建一个全球交互网络 (GIN),集成ncRNA-ncRNA,ncRNA-蛋白编码基因 (PCG) 和PCG-PCG交互.
  • 使用随机步行与重启来量化协会强度 (ASs).
  • 通过基因组丰富分析进行功能注释.

主要成果:

  • ncFN成功地为各种类型的大量ncRNA注释了功能.
  • 与传统方法相比,该框架表现出优越的性能,特别是对于与疾病相关的ncRNAs.
  • ncFN促进了对多个ncRNA或通路的丰富分析.

结论:

  • ncFN是一个全面可靠的工具,用于miRNAs,lncRNAs和circRNAs的功能注释.
  • 该框架适合在ncRNA研究中广泛应用.
  • ncFN是公开的,促进合作研究.