对于多发性硬化症相关的震,深度大脑刺激后的震和残疾结果
Samantha A Banks1, Matthew R Baker2, Eoin P Flanagan3
1Department of Neurology, Mayo Clinic, Rochester, MN, USA; Center for MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.
Multiple sclerosis (Houndmills, Basingstoke, England)
|October 27, 2025
概括
深度大脑刺激 (DBS) 为多发性硬化症 (MS) 患者的严重震提供了潜在的治疗方法,在没有疾病恶化的情况下显示出显著的震得分改善. 针对腹中介核 (VIM) 可能会优化结果.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 医疗技术 医疗技术 医学技术
背景情况:
- 多发性硬化症 (MS) 的往往对药物治疗有抗性.
- 深度大脑刺激 (DBS) 提供了一个替代方案,但具有副作用和疾病恶化的风险.
研究的目的:
- 评估DBS在管理与MS相关的震方面的疗效和安全性.
- 评估DBS对MS患者残疾和震严重性的影响.
主要方法:
- 对18名经过DBS手术的MS-tremor患者进行了回顾性分析.
- 使用扩展残疾状态量表 (EDSS) 和Fahn-Tolosa-Marin (FTM) 震评分来衡量结果.
主要成果:
- 在患者中没有观察到术后复发或新的MRI病变.
- FTM震得分显示显著改善 (中位数为14.5到10,p=0.008).
- EDSS得分保持稳定 (中位数为6至6.25,p=0.2),EDSS为3.5-6.6的患者的结果可变.
结论:
- DBS是一种可行的治疗选择,用于严重的MS相关的震,而不会诱导疾病复发.
- 使用腹腔中间核 (VIM) 作为DBS的唯一目标可以增强震控制并保持MRI可访问性.
关键词:
残疾状况尺度 (EDSS) 是一个标准.多发性硬化症是多发性硬化症.深度大脑刺激 - - 深度大脑刺激,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,更多相关视频
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