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Updated: Jan 14, 2026

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
07:30

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

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一次性途径到Indole-3-acetaldehydes, Tryptophols和Tryptamine-based Alkaloids从Indoles中的一个

Susanta Bhunia1, Ankush Banerjee1, Minakshi Ghosh1

  • 1Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.

The Journal of organic chemistry
|October 27, 2025
PubMed
概括

这项研究引入了一种可扩展的布伦斯特德酸催化技术,用于合成 indole-3-acetaldehydes. 这种方法有效地产生有价值的胺前体和复杂的化物,证明了实用的单方法.

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Preparation of 1° Amines: Azide Synthesis

Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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